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Pet gingivitis treatment
Pet medicine
Interberry-Alpha is
The world's first gingivitis treatment, with canine interferon as the main ingredient, effective in suppressing bad breath and improving gingivitis.
Effective in suppressing bad breath and improving gingivitis, as confirmed by various research results.
Suppresses oral bacteria and has anti-inflammatory effects for a certain period of time through 5 weeks of use
Easy application in gum application form
Convenient to use with a dedicated measuring spoon included (1 spoon is used once a day)
Administration is carried out once a day at 3-4 day intervals for a total of 10 times.
Place one dose of medication on a plate.
Wet your fingertips with water and mix the medicine to make a paste.
Massage the gums from top to bottom, left to right
Apply several times.
Interberry-Alpha Application CASE
If mild or moderate gingivitis is confirmed
Patients who are difficult to anesthetize
Apply after scaling to quickly improve gum inflammation and suppress gingivitis.
“It is important to apply it to the oral mucosa (gums) where immune cells are concentrated.”
nerve cells or immune cells
central nervous system
Other routes
Topical (intraoral)
Improvement and enhancement of immune response
Improve immune imbalance
Systemic immune activation
Induction of antimicrobial substances (β-defensins)
Inhibition of inflammatory cytokines
low-dose INF-α
Oral administration
“It is important to apply it to the oral mucosa (gums) where immune cells are concentrated.”
“moderate gingivitis”
Interberry-alpha user group (n=56)
Interberry-Alpha's Effect on Gingivitis Improvement 1)
“Definite gingivitis”
Control group (n=22)
Interberry-alpha user group (n=29)
Control group (n=17)
Gingivitis index
Gingivitis index
month
Time elapsed after application of Interberry-Alpha
An improvement in the gingivitis index was observed in 124 dogs with confirmed canine gingivitis treated with Interveri-alpha.
deterioration
Interberry-Alpha users
(n=60)
1) Hokusan Corporation development data
Gingivitis index
Percentage of improvement cases
After one month of using Interveri-alpha in feline gingivitis patients with a gingivitis index of 0.5 or higher,
After two months, the gingivitis improvement effect was observed.
control group
(n=32)
Interberry-Alpha users
(n=60)
control group
(n=32)
*: The control group used strawberry powder that had no medicinal effect.
** : P>0.01
improvement
No change
Time elapsed after application of Interberry-Alpha
month
month
score
Long-term effects and duration of Interveri-alpha for gingivitis
Interveri-Alpha twice a week for 5 weeks
A total of 10 doses
Gingivitis Index ＊
Alleviation and persistence of gingivitis by interveri-alpha administration (N=18)
Interbury-Alpha
& toothpaste simultaneous use group
control group
Untreated
Toothpaste users
In patients with canine gingivitis who had not had scaling within the past 3 months, Interveri-alpha showed an inhibitory effect on periodontal pathogenic bacteria* for 9 months when used alone, and the effect lasted for 12 months when used in combination with toothpaste.
* Porphyromonas genus fungi
*When the gingivitis score at the first visit was set to 100
Interbury-Alpha
User group
Interberry-Alpha application
Changes in gingivitis scores after administration of Interveri-alpha (N=13)
control group
Interberry-Alpha application
score
Changes in halitosis scores after administration of Interveri-alpha (N=13)
When Interveri-alpha was administered to patients with mild feline gingivitis who had not had scaling within the past 3 months, a reduction in gingivitis scores and halitosis scores was observed for approximately 3 months.
Jeju National University
College of Veterinary Medicine
May 22, 2020 ~
November 30, 2020
1) Livestock species: Dogs (20 dogs in the treatment group, 10 dogs in the placebo group)
2) Age: 6 months to 10 years
3) Weight: 5 ~ 32 kg
Results of reaction check after application of Interveri-Alpha
√ No immediate reactions (redness, thickening of gums, or hypersensitivity) within 1 hour
√ No delayed reactions (inflammation, appetite changes, and behavioral changes) for 2 weeks
No significant changes were observed in inflammation-related indicators and serum chemical analysis before and after application, confirming that there was no damage to internal organs.
10 times in total, once a day, at 3-4 day intervals
Dosage CALENDAR
Apply 0.275g (1/10 pack) of the main agent per dog evenly to the gums once a day at 3-4 day intervals for a total of 10 times. After administration, it is recommended to re-administer regularly considering the duration of administration (dogs: 9 months, cats: 3 months) .
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